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01/08/11
13:57
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I spoke with Melanie Farris earlier about the announcement. Here are the main points:
* The standard criteria for measuring statistical significance is ACR20 - a 20% improvement in signs and symptoms
* The placebo was methotrexate (MTX). This is the "gold standard" of current treatments. It was not a sugar pill.
* Sub optimal dosing. 75mg of XToll delivered subcutaneously (into the skin) was not the equivalent of doses previously delivered intravenously
* Management believe continued investigation of XToll is warranted at higher doses
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