I spoke with Melanie Farris earlier about the announcement. Here...

I spoke with Melanie Farris earlier about the announcement. Here are the main points:

* The standard criteria for measuring statistical significance is ACR20 - a 20% improvement in signs and symptoms

* The placebo was methotrexate (MTX). This is the "gold standard" of current treatments. It was not a sugar pill.

* Sub optimal dosing. 75mg of XToll delivered subcutaneously (into the skin) was not the equivalent of doses previously delivered intravenously

* Management believe continued investigation of XToll is warranted at higher doses