Ann: IND QUESTIONS RECEIVED FROM US FDA, page-114

Thanks Mozz et al.

I for one would be extremely happy if Zilosul can treat other forms of pain, particularly joints other than the knee.

I have been diagnosed with Adhesive Capsulitis (Frozen Shoulder), they (doctors/shoulder specialist) treated me for Bursitis, ultra sound guided injection into bursa, didn't help the pain or range of movement. I had bursitis in opposing shoulder 4 years ago, and the injection worked, thus why my doc went down that rout first.

Anyway, I have put up with the pain for 2 months. The main issue is sleep, being a side sleeper, impossible to get comfortable and nod off. Up every 2 hours as seated position and ice pack gives me some temporary relief. Has given me a lot of time to do extra reading on PAR and other investments I have on, so thats the plus side of it I guess...

Yesterday I had a CT scan guided injection directly into the shoulder capsule. That was an interesting experience. Pain vanished for 6 hours, then slowly came back, but not as intense. This is normal as the steroid takes 7-10 days to do its job. I am quite an active person, no other health issues and right on my healthy BMI.

Pain while I have motionless is 1-2. Pain if I aggravate the joint can be 8. Motion reduced from the usual 180 degrees to about 110 degrees.

They don't know what causes Adhesive Capsulitis, it usually takes 6-36 months to sort itself out, it can become a pain management issue during that time. This condition could well be a candidate for Zilosul?

This has been my first experience with constant pain while still, and increased level of sharp pain if joint put under stress, so I can understand how those suffering from OA of the knee joint, would be screaming out for relief from a treatment like PAR's Zilosul.

Sorry for waffling on, but I thought Mozz and others would be interested, and perhaps Adhesive Capsulitis is another condition that should be put on the radar of PAR, of its not already. Regards.