INV043 DRAMATICALLY IMPROVED IMMUNE CHECKPOINT INHIBITOR EFFECTIVENESS WHEN
USED IN COMBINATION, ACHIEVING ~80% TUMOUR CONTROL IN PRECLINICAL STUDIES
Highlights:
Topically applied INV043 in combination with an immune checkpoint inhibitor (ICI)
resulted in ~80% of subjects being tumour-free. The study was conducted by Peter Mac
using immune competent anal squamous cell carcinoma (ASCC) in vivo models
ICIs, the standard of care for the treatment of several cancers, are a class of
immunotherapy drug. Despite widespread clinical use as a monotherapy, ICI
effectiveness is typically limited to a small proportion of patients
Results support previous findings by Hudson Institute using intratumorally administered
INV043 in combination with ICIs on another cancer type (triple negative breast cancer)
Opens additional treatment options for upcoming clinical trial programs that span
multiple cancers
ASCC has potential to be designated as an orphan indication – leading to an expedited
regulatory approval process
The findings reinforce the potential for collaboration partnerships using combination
therapies to extend the patent life of blockbuster ICIs
Global ICI market forecast to grow at 16.8% CAGR to reach US$189 billion by 20321
Sadly they didn't mention the ICI, but imagine if it was KEYTRUDA. Merck would be making an offer straight away.
Anyway, that's a cracker anns.
Should touch 1c tomorrow at least.
GLTA
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