Ann: Investigation of Concerns around CEO Share Trading, page-2

That investigation has now been completed, and a report from Watson Mangioni has been provided to,
and considered by, the Board. The contents of that report are privileged and confidential.

After due consideration, the Board of Sirtex has today terminated Mr Wong’s employment with Sirtex,
with immediate effect. Mr Wong’s salary and statutory entitlements will be paid to the date of
termination. All unvested performance rights previously issued to Mr Wong have been forfeited.

Mr Nigel Lange has been appointed as Acting CEO, effectively immediately. Mr Lange is the current
Chief Operating Officer of Sirtex, with over 14 years direct experience in the core SIR-Spheres ® Y-90
resin microspheres business.

Mr Lange commented “I look forward to delivering on our strategies, to maximise the potential of our
SIR-Spheres microspheres technology, and to reinstate value to our shareholders.”

Sirtex will be conducting a thorough executive search and recruitment process to fill the position of
CEO and intends to appoint an executive search firm to oversee this process and conduct a global
search.

Separately, Sirtex is pleased to announce the appointment of Anthony (Tony) Dixon as the incoming
Chief Executive Officer, EMEA with immediate effect.

Mr Lange noted that “Tony has been with Sirtex Medical Europe for nine years and has a strong track
record in oncology and the medical devices sector, having served as National Sales Manager UK,
Director of Marketing and more recently the Vice President of Marketing EMEA.”

He also stated that he expects the appointment of a Chief Executive Officer, APAC will be made prior
to the end of January.