Yep, after looking at the chart again, it illustrates the normal...

Yep, after looking at the chart again, it illustrates the normal route that those patients whose tumour can (and has to) be surgically removed or reduced which is the SOC would have to go through before receiving our therapy. So, you are correct, Reon.... and besides, control arms are generally only part of Ph3 trials from what i understand.

With this being the case, I wonder why the Ommaya reservoir method not being considered for the delivery of CLTX CarT cells(?)

Ommaya Reservoir Placement

An Ommaya reservoir is a device implanted under the scalp, connected to a catheter that leads into the brain. It's commonly used in the treatment of GBM and other brain cancers for several purposes:

1. Delivering Chemotherapy: Allows for the direct administration of chemotherapy into the cerebrospinal fluid (CSF) or the tumor site, bypassing the blood-brain barrier.
2. Aspirating CSF: Enables the removal of CSF for testing or to reduce intracranial pressure.
3. Administering Other Treatments: Facilitates the delivery of other therapeutic agents, such as targeted therapies or immunotherapies, directly to the brain.
4. Reducing Tumor-Related Symptoms: Can be used to manage symptoms associated with brain tumors, such as hydrocephalus (buildup of fluid in the brain).

The Ommaya reservoir is a valuable tool in neuro-oncology, particularly for patients with tumors like GBM that are difficult to treat with conventional methods.