an ALSFRS-R decline of less than 1.24 per month under 1.0 is gamechanger and under 0.8 is new world order ; )
Besides that, safety profile and tolerability.
Survival of better than 9 months (current SoC).
The last two points have in effect already been validated and it’s the first to see the extent of the improvement that will be most interesting.
Ann: Investor webinar - Phase 1 MND Study Top-Line Results, page-178
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