PAR 3.85% 25.0¢ paradigm biopharmaceuticals limited..

Ann: iPPS Demonstrates Multiple DMOAD Signals in Phase 2 Study, page-4

  1. 4,124 Posts.
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    Mate...now that's what I call a good data read out.

    I knew about Womac Pain, Function and PGIC from the consistent evidence of all the past studies...

    I understood about the Wet Biochemical Markers - we got a nice Graphic Equaliser effect indeed....



    https://hotcopper.com.au/data/attachments/5174/5174585-9a4fdc1b8fbeab724141d85ea500371c.jpg

    The graphic equaliser moving in our favour and with great p values to boot.



    ...but, structurally, I always knew this would be a trump card if we got it right..

    Show meaningful separation here....divergence between the active and the placebo...and we have something even more special.

    Isn't 6 months just too early to actually display meaningful reductions in physical attributes? Yes the biology would've well and truly started but it takes time to manifest into observable readings and measures... specially in a slightly older demographic....cartilage, bone, joint tissue turn over is much more prevalent in a younger cohort...this was my slight worry, I thought we may need to wait more like the 12 month read out to get a clear reading here??


    We have not only shown a sneak peak at 6 months..we have BLOWN it out of the water!!


    https://hotcopper.com.au/data/attachments/5174/5174381-2977721dd7e0927bf4ea5e359273473f.jpg
    Made a splash? Incredible! Imagine what's to come now...



    38% reduction in BML's in active -v- what reduction was there in Placebo???

    Wrong



    ...it wasn't a DECREASE....it was an INCREASE in Placebo....was it marginal? Guess again...

    47% Up.



    38 % DECREASE in active group compared to 47% INCREASE in Placebo... !!!



    Femoral Compartment?

    Decrease of 17% versus a massive 56% increase in placebo group.


    Cartilage?

    21% Improvement in cartilage versus 4% worsening !!!!


    Rescue Medication connotations?

    Much lower usage amongst active to day 168 (4 times!)




    I N C R E D I B L E







    A very special THANK YOU to the PAR staff, you have done a tremendous job in getting us this far. I know the hours you have all done...some of you don't get your name in lights, you may not get much of a mention on the reports...it is NOT LOST ON ME, and my fellow shareholders and owners of this amazing company.

    Thank you for making our futures brighter...

    This result is quite simply stupendous.

    Chalk and cheese....to get these results in just 6 months shows the real power of our drug.



    Bravo!



    Mozz




    https://hotcopper.com.au/data/attachments/5174/5174422-72169db76601286a6017eb2f59eb8a4b.jpg





    DYOR is good

 
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