Ann: iSonea Achieves TGA Approval for Listing of , page-9

re: Ann: iSonea Achieves TGA Approval for Lis... correction

"Instrument maker Masimo use's a pulse oximeter to measure a persons Acoustic Respiration Rate" should be "Instrument maker Masimo use's a pulse oximeter to measure Pleth Variability Index (PVI) . The Acoustic Respiration Rate is measured from another Masimo device which is attached to the throat to monitor patients.

Pleth Variability Index - Clinical Implications

"In the case of severe asthma, the airway resistance increases the intrathoracic pressure during
peak inspiration, resulting in a transient decrease in venous return and thereby causing a decrease in stroke volume output of the heart resulting in pulse pressure variation. In the case of hypovolemia, the pressure (or volume) within the vascular space is lower and is more greatly impacted even by relatively minor changes in airway pressure even during normal respiration thus resulting in cyclical changes in stroke volume output of the heart. This relationship inverts during mechanical ventilation as the airway pressure patterns invert; air is drawn in via negative pressure during spontaneous ventilation whereas it is pushed in via positive pressure during mechanical
ventilation. So, mechanical ventilation may have a more pronounced impact on impeding venous return and increasing this cyclic variation.
These cyclic changes that occur due to alteration in physiology have been described by various terminologies: systolic pressure variability, pulse pressure variation, delta up/delta down and respiratory waveform variation

http://www.masimo.com/pdf/whitepaper/LAB4583A.pdf

http://ir.masimo.com/phoenix.zhtml?c=117065&p=irol-newsArticle&ID=1287849&highlight=