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clock Created with Sketch. 10/01/23
13:56
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Originally posted by BobF:
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"... I see they are still claiming they have reached human IV dose rates equivalent to efficacious dose rates in animals. They fail to mention that this dose rate achieved plasma concentrations which were multiples lower than achieved in animals. Oh well, at least it looks like 327 could be a massively powerful UTI antibiotic, even if it doesn't end up being capable of treating bacteraemia/sepsis . ..."absolutely sure that efficacy has not been achieved at those rates? Are you absolutely sure that these plasma levels in humans are ineffective based on animal levels? Is there no way that the animal levels were tested up to far higher rates than absolutely necessary? Given that presentation, if what you say is correct, I think that omission would be more than "failing to mention", it would be downright misleading. Is that what you are suggesting? That their efficacy claims in humans are false?
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This is based on Recce's data. May be achieving plasma concentrations above MIC for E. coli, but no other ESKAPE pathogens.
Last edited by
reon1 :
10/01/23
(20min delay)