Actually, at least one of the historical studies was in children - study 5. From 6 minutes in:
https://www.finnewsnetwork.com.au/P...storEvents_2018/11Oct/RaceOncology/index.html
Also, a jump from 15% to 22% could have a significant impact on Bisantrene efficacy in salvage patients if you assume the extra 7% would have been in the group of those who responded to Bisantrene in the earlier studies.
You must adjust the success rate down accordingly.
Actually, at least one of the historical studies was in children...
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