Some interesting points from E & P's note today as the results were better than anticpated:
• To put this result into context: Sarepta’s (NASDAQ:SRPT) drug candidate (SRP-5051; a similar peptide-conjugated oligonucleotide to PYC-003) for Duchenne muscular dystrophy (DMD) also showed a dose dependent and sustained exposure persisting for 28 days, but from double the initial dose (60 mg/kg) and at fraction of the concentration in muscle tissue (~500 ng/mL) that PYC observed in the kidneys at an equivalent time point (>30,000 ng/mL; the actual concentration was above the quantitation limit of the assay).
• Importantly, SRP-5051 at this markedly reduced PD profile to PYC-003 was able to generate ~20% exon skipping.
• Based on these data, PYC-003 could achieve day-30 target tissue concentrations orders of magnitude greater than SRP-5051.
• Obviously PKD and DMD are different conditions in different target organs, but the pharmacodynamic implications of this comparison are relevant and encouraging.
• Taken together, this suggests that PYC-003 could be dosed and tolerated well above the putative therapeutic range (1 – 5 mg/kg), achieving impressive target tissue concentrations, with significant safety headroom.
- Forums
- ASX - By Stock
- Ann: Kidney Disease Drug Candidate Progressing to Human Trials
Some interesting points from E & P's note today as the results...
-
- There are more pages in this discussion • 11 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add PYC (ASX) to my watchlist
(20min delay)
|
|||||
Last
13.0¢ |
Change
0.000(0.00%) |
Mkt cap ! $606.5M |
Open | High | Low | Value | Volume |
13.5¢ | 13.5¢ | 12.5¢ | $17.86K | 137.7K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
11 | 1081168 | 12.5¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
13.0¢ | 505604 | 2 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
10 | 1069168 | 0.125 |
11 | 1346557 | 0.120 |
12 | 1239403 | 0.115 |
10 | 403370 | 0.110 |
13 | 1221009 | 0.105 |
Price($) | Vol. | No. |
---|---|---|
0.135 | 537674 | 5 |
0.140 | 1117191 | 5 |
0.145 | 256800 | 2 |
0.150 | 525000 | 3 |
0.165 | 23000 | 1 |
Last trade - 16.10pm 05/07/2024 (20 minute delay) ? |
Featured News
PYC (ASX) Chart |