I'd love to see a study with a combination of intravenous and local injections of MSCs for SR-GVHD. I've got a feeling that the results would be amazing. Given the success of direct application of MSC for perianal fistula it stands to reason that shifting the focus further up the GI tract (to where the issues are truly life threatening due leaky gut and abscesses in the colon inviting infection and organ failure) that there would be additional improvements in mortality over and above those shown in the intravenous treatment.
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