MSB 8.25% $1.05 mesoblast limited

They way I see it is:Significant reduction in recurrent...

  1. 5,481 Posts.
    lightbulb Created with Sketch. 8927
    They way I see it is:

    Significant reduction in recurrent hospitalisations + reduction in mortality = best result, could go for accelerated approval + big partner guaranteed

    Significant reduction in mortality only = next best outcome, still have a chance for accelerated approval + big partners would be interested, but not guaranteed.

    Significant reduction in recurrent hospitalisations only = bad outcome, no chance of accelerated approval + no big partners would be interested.

    No improvement in any of the primary or key secondary endpoint = disastrous outcome.

    The meeting with the FDA will be very interesting... 60% reduction in mortality in Class II patients is going to catch the attention of big pharmas, but how strong the case is for partnership will depend on what the FDA says as well as how all the other secondary endpoints stacked up ... because the p values generated for mortality in such a small patient population (relative to others using mortality as an endpoint) may be able to stand on it's own two feet for approval (p=0.037). MACE events may be the preferred primary end-point in the confirmatory trial, with mortality the key secondary endpoint (to reduce patient population required).

    My guess is that CLBP read-out will come out later this week, and the longer the COVID ARDS 60% read-out remains unannounced ... the more likely we'll get a positive read-out IMO.



    Last edited by stockrock: 15/12/20
 
watchlist Created with Sketch. Add MSB (ASX) to my watchlist
(20min delay)
Last
$1.05
Change
0.080(8.25%)
Mkt cap ! $1.198B
Open High Low Value Volume
99.5¢ $1.06 99.0¢ $4.930M 4.779M

Buyers (Bids)

No. Vol. Price($)
1 23545 $1.05
 

Sellers (Offers)

Price($) Vol. No.
$1.05 339479 5
View Market Depth
Last trade - 16.10pm 04/07/2024 (20 minute delay) ?
MSB (ASX) Chart
arrow-down-2 Created with Sketch. arrow-down-2 Created with Sketch.