Opioids rely on the analgesic effect to help initial perceived functional improvements. The problem is it wears off quickly as the body signal it needs an every increasing dosage. Here is an interesting link I came across on how the clinical process works for doctors before prescribing. I suspect its a direct consequence of the SAEs they see after prescribing (and no doubt the potential exposure to future litigation)
https://www.health.qld.gov.au/__data/assets/pdf_file/0021/444432/quick-clinical-guide.pdf
Ann: Mesoblast Phase 3 Chronic Low Back Pain Results, page-346
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