mneumonic has to do with the details of the patent. Its all explained in this section (pretty clearly)
- In the context of the example described herein, the transdermal delivery device preferably produces and delivers an electromagnetic field to the dermal or mucosal surface wherein the field delivered is defined by a mnemonic profile of: [(A-B-C-D)E], [(A1-B1-C1-D1)E1]
- where:
- A and A1 respectively define the number of 400 μs time units that the electromagnetic field pulse is on for wherein each of A and A1 is a number between 0.1 and 10;
- B and B1 respectively define is the number of 400 μs time units the field is off for wherein B is a number between 0.1 and 100, while B1 is a number between 0.1 and 100;
- C is a number between 1 and 255, which defines the number of times the A and B combination is repeated, while C1 is also a number between 1 and 255 and defines the number of times the A1 and B1 combination is repeated;
- D and D1 respectively define the number of 400 μs time units that the field is off for wherein D is a number between 0 and 255, while D1 is a number between 0 and 255; and
- E defines the number of times the A to D envelope is executed before moving onto the [(A1-B1-C1-D1)E1] packet, while E1 defines the number of times the A1 to D1 envelope is executed before moving onto the next mnemonic profile wherein E and E1 are respectively numbers between 1 and 25.
EXAMPLES
- The mnemonic profile selected can differ according the drug administered and also due to a number of environmental conditions, including but not limited to the skin type of a user, the general environment (i.e. the local temperature, humidity and pressure) and any other factors which may affect the efficacy of the transdermal delivery.
- In use, a mnemonic profile type is selected by the device as disclosed later in this document. In particular, the mnemonic profile type is selected according to the nature and properties of the formulation or active ingredient being administered.
https://patents.google.com/patent/US20160279434A1/en
- By way of example, a mnemonic of [(2-12-100)255], [(2-12-50)155] (i.e. A=2, B=12, C=100, D=0, E=255, A1=2, B1=12, C1=50, D1=0, E1=155) is one possible mnemonic that has been shown through research and testing to provide enhanced delivery of a water soluble molecule of around 400 daltons from a conventional oil in water emulsion when applied to a person of Caucasian skin type, between 50-60 years of age in standard temperate and atmospheric pressure conditions.
- However, individuals who have different skin characteristics may not be well served by this standard mnemonic, in which case, the mnemonic is adjusted depending on their individual skin characteristics.
- By way of example only, if the person was of Chinese ancestry and 25 years of age, the mnemonic would optimally need to be adjusted to accommodate the higher skin lipid content and the less effective hydrophilic delivery pathway that would otherwise be available in Caucasian skin types. In such a case, the mnemonic may be optimised to program the transdermal delivery device with a mnemonic of [(2-12-75)255], [(2-18-100)100] which changes the lipophilicity of the mnemonic and provide greater diamagnetic force to overcome the higher thermodynamic barrier to partitioning of the active ingredient into a more oily environments.
- In yet another example, the same formulation may be optimised to suit an older person of Caucasian ancestry living in a hot and dry climate. In such a case, natural perspiration and the underlying skin type may provide an efficient hydrophilic path via the skin's appendageal system that can be further enhanced by modifying the mnemonic to [(4-12-50)255], [(2-12-50)255]. In such a case the greater period of magnetic flux may increase diamagnetic repulsion, while the more inductive portion of the second part of the mnemonic may enhance partitioning of the active ingredient into this more aqueous environment.
- In yet another example, a similar older person of Caucasian ancestry with physical skin characteristics (as described in the previous paragraph) but living in a hot and dry climate may wish to apply an anti-aging formulation made up of a high molecular weight oligopeptide of 800 daltons in size in a lipophilic formulation. In such case, natural perspiration and underlying skin lipid content may provide a challenging delivery pathway. Aided by the data relating to both the user and the nature of the formulation, a modified mnemonic of [(5-25-50)10], [(2-50-2)50] may be used to overcome the thermodynamic barriers to partitioning and diffusion into the skin and enhanced delivery via the lipid bilayer's storage potentials.
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mneumonic has to do with the details of the patent. Its all...
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