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Ann: NTCELL Parkinsons trial patient data 2 years after implant, page-56

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whytee

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15/05/19

22:57

Post #: 38585446
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Originally posted by Southoz ↑

Hi Whytee …. not sure … the results announcement is so poorly presented its hard to make head nor tail of what is going on.

The flavour I get is that the trial was approached with a very confirmatory bias. Surgery is risky and so you need a big benefit to justify it. That benefit is either shown or not at 26 weeks.

Once that failed the exploratory longer follow-up idea comes into play. But the methods / statistical approach is based around the confirmatory model. Taking a slice in time:

At 6 months sig/ns
At 12 months sig/ns
At 18 months sig/ns
etc

The exploratory approach is to fit a curve to the change over time; is there a trend for improvement over time for the treatment groups. And the more time points you have for this the better; particularly when the N is small.

Expand

Maybe N was just a bit too small given all the variables...
Still it was a "trial", a lot has been learned, it isn't necessarily over yet, and many great advances have had setbacks during development.

LCT Price at posting: 2.9¢ Sentiment: Hold Disclosure: Held
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Ann: NTCELL Parkinsons trial patient data 2 years after implant, page-56

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Ann: NTCELL Parkinsons trial patient data 2 years after implant, page-56

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