I appreciate that we have clinical data to support Monepantel with autophagy.
But, did we have data for neurological disorders ? Seems we have now ( in part)
So remembering that good news is positive news in the science spectrum.
Why the embargo when there is possibly 1000 to 1100 submissions, I lost count ( took me 3 hours with occasional breaks to read each headline), I can't answer that .
But a quick explanation of what they were or are trying to achieve.
NSC-34 ( Vienna study) A hybrid cell line derived from the fusion of embryonic mouse spinal cord motor neurons and mouse neuroblastoma cells. It exhibits properties of motor neurons, including choline acetyltransferase expression and acetylcholine synthesis. Highly relevant to Neurological disease processes.
OVCAR3 ( 2014 study): A human ovarian cancer cell line derived from a high-grade serous (HGS) ovarian carcinoma. It is epithelial in origin and primarily used for ovarian cancer research.
A2780 ( 2014 study) A human ovarian cancer cell line established from an untreated ovarian endometrioid adenocarcinoma. It has an epithelial morphology and is widely used in drug resistance and metastasis ( cancer) studies.
So now we have another modicum of data to substantiate effectiveness in relation to autophagy.
Each cell line serves distinct research purposes, with NSC-34 being neuron-focused, while OVCAR3 and A2780 are cancer models with differing histopathological origins and metastatic potentials.
3D disease models offer higher predictive power for drug development and disease mechanisms while reducing ethical and translational limitations of animal testing. Their ability to mimic human tissue complexity makes them indispensable for precision medicine and therapies.
We are progressing through all this albeit slow.
Just for clarification. 5uM is approximately 2.6 mg/kg and 50 uM is approximately 26 mg/kg as opposed to standard Healey dose of 10mg/kg .
Three day testing may suffice for preliminary in vitro proof but we need longer data . My question is why didn't we do it then,so by now that guess work would be completed.Its been 3 months. Why would we slow the show down ?
I get highly exasperated to tell to the honest truth. You know my thoughts on this drug, get it out in the streets as soon as possible, not as soon as plausible. It's already plausible.
Kpax
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