I know a lot has been said about these abstracts. I jus thoughts I'd read through them and break down one of them (for my own benefit - and perhaps others)...Eureka + IMU...the below is taken from the abstracts...(except bolded titles).
Problem: HCC - second in the world!
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in the world
Current treatment: Liver transplant, removal of tumor but even so a 5-year survival rate at less than 12%.
Current problems with solid tumours...
a. Tumor express many different targets (antigens).
b. Micro- enviroment (TME) suppresses Immune system.
Oncarlytics + T cell Eureka...
a. Puts a target on tumor. (solves problem a - above)
b. OV - reshapes the TME. (solves problem b above).
Conclusion...
"In summary, ARTEMIS® CD19 T cells combined with onCARlytics is a potentially effective immunotherapy strategy for the treatment of patients with HCC and can be applied to other solid tumors"
I know this is a. only pre-clinical and b. is there interest with BP? However the magnitude of this is just staggering, even if it only comes off at 20% of the potential.
DYOR and all that.
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Ann: onCARlytics to be showcased in three abstracts at SITC, page-81
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