Ann: Optiscan Imaging Acquires Intellectual Property, page-14

remember watching a video explaining... presented by a leading doctor/ proffessor... the holy
grail for confocal endomicroscopic imaging is the application of fluorescein ...enabling
identification of cell parts and specifically cancer...
first bullet point in todays ann...
"Improvements to the Company’s current and future US FDA 510(k) submissions for use of
fluorescein (in vivo use) and acriflavine (ex vivo use) as topical contrast agents for
determination of cellular microstructure, and diagnostic and surgical utilisation "
jimo...this data that gets us closer to the holy grail

researchgate article published 4/10/22
"Confocal laser imaging in neurosurgery: A comprehensive review of sodium fluorescein-
based CONVIVO preclinical and clinical applications
https://www.researchgate.net/publication/364115828_Confocal_laser_imaging_in_neurosurgery_A_comprehensive_review_of_sodium_fluorescein-based_CONVIVO_preclinical_and_clinical_applications
Good read and a very positive report...

"In conclusion, considering also the possible future applications that this machine may
demonstrate inneurosurgery, the analyzed publications show promisingdiagnostic
performance of CONVIVO compared to standardmethods in histopathology "
Also advancing the use of CLE ...
"At this time, three centers are running larger clinical trials (a multicenter trial in
Germany: INVIVO, NCT04597801 (52); a trial in Berne,Switzerland: CLEBT,
NCT04280952 (53); a trial in Milano,Italy: Besta Institute Review Board, verbal
n. 72/2020),focusing on the concordance of CLE with definitive histopathological
analysis "

just a matter of time..imo glta