Ann: Paradigm to Present at Evercore ISI HealthCONx Conference, page-182

Notwithstanding the negatives raised here regarding timing, costs, disclosure etc there is also an upside to increasing trial size and that is statistical significance is a function both the result and the numbers that result is based on. The exam may take longer but the pass mark is lower by virtue of sample size increase. Having said that there is also a law of diminishing returns in this regard. I'm not arguing with any points here - However, in weighing it all up for myself I am reminded of how concerned Paul was of not stuffing up submission and that there is an upside which warrants consideration - I just don't know by how much an increase of 350 or 500 or whatever derisks the trial outcome. It would have been a good question for our recent vote.