Ann: PBT434 Lowers Alpha-Synuclein and Prevents Neurodegeneration, page-10

chucke.. the answer is.. YES !! it does

feel free to 'woof' this down from the linked article:

"The collection of cerebrospinal fluid (CSF) was performed at the conclusion of a 28 day toxicology study in 10 month old Beagle dogs undertaken at Charles River Laboratories Preclinical services Edinburgh UK under appropriate ethics approval. PBT434 was administered by oral gavage once a day for 28 days at the following doses: vehicle control (0 mg/kg/day), 10 mg/kg/day, 30 mg/kg/day and 50 mg/kg/day. Each treatment arm included 3 male and 3 female dogs. The CSF was extracted at necropsy into collection tubes containing 10uL of butylated hydroxytoluene, frozen on dry ice and stored at −80 °C until analysis. Any samples showing signs of hemolysis were excluded due to the potential for contamination of α-synuclein from blood [52]."

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"In a small exploratory study, CSF collected post-mortem from dogs undergoing a 28 day dose-tolerability study of PBT434 was assayed for soluble α-synuclein a dose dependent trend (non-significant) in the reduction of α-synuclein was observed (Fig. 7a)"


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"Examination of samples of post-mortem CSF from healthy dogs treated with PBT434 for 28 days showed a significant dose-dependent reduction in α-synuclein, an effect also observed in rats fitted with an indwelling ventricular catheter, consistent with the hypothesis that PBT434 modulates α-synuclein expression at the translational level. "