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It's because of the phasing of the MEND trial (see below)The 6...

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    It's because of the phasing of the MEND trial (see below)

    https://hotcopper.com.au/data/attachments/6262/6262194-34906af9bae0f7eb47e435e24e0b9b84.jpg

    The 6 patients at the later time points are from the "low dose" Cohort 1 which started first. The data out there is a bit messy likely because of the smaller patient numbers and minimally effective dose level.

    When Cohort 1 and the "high dose" Cohort 2 were separated out, the effect of the higher dose (which is what will be used in the STRIKE study) becomes more obvious and compelling.

    https://hotcopper.com.au/data/attachments/6262/6262220-083b9671970dc78c9c677a2de9de8282.jpg

    https://hotcopper.com.au/data/attachments/6262/6262221-de09f8c5104970db5bb17c0f9004f61b.jpg

 
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