For point 5, not great medical knowledge here either, but if higher dose levels can be achieved safely one would expect that this could be used to help counter any resistance to CF33. Similarly other CF virus constructs might also be used so CF17 might have a role to play or a slightly reengineered CF33 construct to be effective again. From current indications re-administration or dose escalation seems feasible. I guess it will be interesting to see what the persistence of the virus will be long term to combat a relapse or any other cancer variant that may appear. I am not sure if these longer term outlooks for ongoing effectiveness is available through any preclinical results to date.
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