"Based on what" fair call but based on long conversations about complicated mechanisms of acne from an expert, and yes IMO.
And no, you cannot eliminate the vehicle (Permetrix) in the trial so the results of phase 3 will demostrate the trial was flawed for good or bad. The fact is you require more from the study than the study set out to demonstrate. Baby steps, you can be right or wrong but you are neither at this point, just creating a straw dog.
Ann: Phase 2a Study Shows BTX 1801 Eradicates S. Aureus, page-586
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