This text is hyperlinked but does not show that way, i.e. blue,...

First 238 Last

Share
Profile

Follow
Treed

3,902 Posts.

1325

15/10/20

20:04

Post #: 48129533
Share

Originally posted by Treed: ↑

OK, now I'm really PO but quite happy the message might finally be getting through, I've been trying to post this since about 16:15
--------------------------------------------------------------------
OK, I'll bang away at this general subject, again

@kervio if this holds true;

" The reason the DSMB is there is to steer the trial without unbinding the results, so if there are factors external to the trial that change how the trial should be designed then they will be factored into the recommendations of the committee and the response from the sponsor."

And the sponsor is the Icahn School of Medicine at Mount Sinai, with Mesoblast listed as Collaborator, the funding is supplied by the NIH for a project aimed ostensibly solely at finding a cure for COVID-19 ARDs, with the funding supplied after the current Public Health Emergency was declared, and it is possible the CTSN supply the DSMB (they have protocols in place for running them), with the CTSN funded by the NIH. Additionally as I've previously stated both the NIH and the FDA are members of the Public Health Emergency Medical Countermeasures Enterprise which was activated before the trial beganAlso consider this angle;

From https://www.phe.gov/Preparedness/mcm/phemce/Pages/mission.aspx

Is it possible that the DSMB may also report to the NIH as well as Icahn? Is the sponsor the only party who can close down a trial during a Public Health Emergency if the trial has met pre-defined parameters in relation to the Emergency, that would not normally be considered outstanding efficacy? Just a considerably better survival outcome than currently available, at some pre-defined improvement.

And I note the info with the usual disclaimer, my bold, referred to by @Stickshift FDA guidance (non-binding) to DSMBs

It is a question I do not have an answer to. Perhaps I will ask.

Expand

This text is hyperlinked but does not show that way, i.e. blue,

Public Health Emergency Medical Countermeasures Enterprise
https://www.phe.gov/Preparedness/mcm/phemce/Pages/default.aspx

MSB Price at posting: $3.21 Sentiment: Buy Disclosure: Held
Upvote

0 Great analysis

Reply

Top Stories

Finance school vs reality: What they don't teach you about the stock market

'We're looking': Nickel-rich Indonesia sounds graphite warning to Aus producers

Making money: How many microcaps should be in an investor's portfolio?

MKT

The ASX can overlook its Telecomm small-caps. Here’s one diversified brand with an international footprint

The Altcoin Landscape (Part 1): Key alternative cryptocurrencies to watch

There are more pages in this discussion • 208 more messages in this thread...

First 238 Last

Add MSB (ASX) to my watchlist

(20min delay)
Last $1.31		Change 0.040(3.16%)		Mkt cap ! $1.490B

Open	High	Low	Value	Volume
$1.28	$1.32	$1.26	$3.433M	2.652M

Buyers (Bids)

No.	Vol.	Price($)
2	39558	$1.30

Sellers (Offers)

Price($)	Vol.	No.
$1.31	21776	3

View Market Depth

No.	Vol.	Price($)
2	39558	1.300
3	26433	1.295
6	108207	1.290
2	47468	1.285
3	10889	1.280

Price($)	Vol.	No.
1.310	21776	3
1.315	57441	5
1.320	2500	1
1.325	61160	4
1.330	15000	2

Last trade - 16.10pm 28/10/2024 (20 minute delay)

MSB (ASX) Chart

This text is hyperlinked but does not show that way, i.e. blue,...

Finance school vs reality: What they don't teach you about the stock market

'We're looking': Nickel-rich Indonesia sounds graphite warning to Aus producers

Making money: How many microcaps should be in an investor's portfolio?

The ASX can overlook its Telecomm small-caps. Here’s one diversified brand with an international footprint

The Altcoin Landscape (Part 1): Key alternative cryptocurrencies to watch

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News

This text is hyperlinked but does not show that way, i.e. blue,...

Top Stories

Finance school vs reality: What they don't teach you about the stock market

'We're looking': Nickel-rich Indonesia sounds graphite warning to Aus producers

Making money: How many microcaps should be in an investor's portfolio?

The ASX can overlook its Telecomm small-caps. Here’s one diversified brand with an international footprint

The Altcoin Landscape (Part 1): Key alternative cryptocurrencies to watch

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News