Ann: Photosoft efficiently destroys ovarian cancer cells in vitro, page-2

100% cell death -got to love those results


― PhotosoftTM caused efficient and highly effective cancer cell destruction in vitro Melbourne, Australia, 5 July 2018: Invion Limited (ASX: IVX, “Invion” or “Company”) is pleased to announce that initial characterisation of the novel chlorophyll based photodynamic therapy, PhotosoftTM in ovarian cancer has been completed under its Research & Development Alliance Agreement with leading Australian medical research institute, Hudson Institute of Medical Research (“Hudson Institute”). Spectral characteristics, cellular uptake and clearance, intracellular localisation, dark and photo-toxicity were investigated in multiple ovarian cancer cell lines (human and murine) in both 2D and 3D organoid culture in vitro. PhotosoftTM caused efficient and highly effective cancer cell destruction in vitro, with 100% cell death achieved in a matter of minutes following light activation. In the absence of light activation, PhotosoftTM was completely non-toxic to cells – highlighting its potential for clinical application without inducing non-specific phototoxicity, a major impediment experienced in the clinical application of other photosensitiser compounds. Photodynamic Therapy (PDT), combining a photo-sensitising compound and light