Kudos for researching 58 ICU patients in NSW and Victoria at 31 August.
But the trial was flawed in design it wouldn't have mattered if they'd completed with 24 patients or not if standard of care varied so much that it wasn't possible to meaningfully compare standard of care (as a reliable base - it would be like using a rubber or elastic ruler to measure distance) with treatment.
Standard of care needs to be relatively fixed to give a basis for comparison - it wasn't sufficiently. Things like prone positioning in ARDS (which depends on having numbers of people to turn the unconscious patient and so is a bit of a luxury when ICU staff are run off their feet) can introduce maybe 15% better results in itself. 24 recruited would have been 12 versus 12 - the sample size is small so it can't absorb (average out) differences in standard of care as well as a larger sample size.
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