Ann: Positive Interim Study Results from OLE Study in ALS, page-50

Correct. Very good pickup! @LongTony

I'd noticed as well.

3.4 chances in 10,000 that the statistics are by chance.

The survival results:

• A p-value of .0022 is very small - (previous)
• A p-value of .00034 is tiny - (current)

signify an extremely small probability,

that the observed results were due to

random effects,

error,

false positives,

or variation.

i.e. by chance.

This infers that these results are highly amazing statistically significant results.

This infers that MPL works, and works extremely well.

In addition, we have reproducibility in the results.

The increased statistical significance infers the great degree of accuracy of reproducibility.

This means very strong evidence for replication of results.

In many ways,

these new numbers build really well on the previous numbers,

and are so much stronger results.

The predictive quality for the P2/3 is greatly enhanced.

cheers,
Ice