Well this is the best news in a long while...
"
In an oral presentation, Prof. Adnan Khattak, Consultant Medical Oncologist at Fiona Stanley Hospital and a principal investigator of the on-going TACTI-mel study, showed efficacy and safety data from 18 patients in part A, the dose escalation part of the study, and first safety data from 6 patients in part B.
In part A, dose escalation, combination therapy started after four cycles of KEYTRUDA® monotherapy. In part B, patients were treated with the combination from the first day of treatment i.e. receiving efti from day one, cycle one with KEYTRUDA®.
The efficacy data from part A was encouraging and supportive of previously disclosed response rates with a 33% Overall Response Rate (ORR) when measured from start of the combination at cycle 5 of KEYTRUDA®. The ORR was 61% when measured from the start of KEYTRUDA® monotherapy treatment in an explorative analysis measuring from cycle 1, day 1. A disease control rate of 66% was reported from the combination treatment. The patient population was partly pre-treated before the start of KEYTRUDA®, suboptimally responding to KEYTRUDA® and the majority had increased risk factors.
In both parts (A and B), combination therapy has been well tolerated with no dose-limiting toxicities and local erythema and injection site reactions as the most common side effects. Importantly the safety data of part B supports the dose scheduling of the Company’s planned Phase II TACTI-002 clinical study in collaboration with MSD."end
It works...its safe..and we are now on the world stage. Great things will follow.
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- Ann: Positive interim TACTI-mel data presented at SITC
Ann: Positive interim TACTI-mel data presented at SITC, page-4
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