Ann: Positive results from AI-116 in vitro studies, page-2

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Figure 1. Average percentage increase in cell survival relative to amyloid  treated control cells. Zero is the benchmark for AB effected cells with no treatments, whereby cell viability was 65.5%. Cell viability increased by 2.1% to 67.6% for Donepezil, by 11.6% to 77.1% for CBD and by 20.1% to 85.6% for AI-116. These results demonstrate that the combination of CBD and Donepezil synergise to increase the neuroprotective effect in neuronal cells that are exposed to toxic Amyloid β, with the observed combined effect of the two drugs on cell viability is 33% greater than what would be expected if we added together the effects of each drug used alone.