hmmm yes sort of all the above varied thoughts
the big issue for efficacy trials is that patients with sepsis often in hospital in dire life threatening situation
to ask dtrs to first administer recce as first line of defence rather that go down the old route of randomly applying known penicillin derivatives then awaiting petrie dish results over days to narrow in on the “next “ possible solution
is a difficult hurdle to overcome
thats why this toxicity trial is so important
if there is no issues with administering it up front then why not then they are not risking time and deterioration in the patient than would otherwise be the normal current case
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