50mg/kg (4,000mg infusion for 80kg person) is the expected effective dose based on previous presentations, but I'm sure its pretty rough indication.
Bacteria have different MICs (minimum inhibitory concentration) and MBCs (minimum bacteriocidal concentration) for different antibiotics, and even these can vary depending on other factors.
Then there's pre-sepsis conditions such as bladder and kidney infections. The target IV dose may be higher for those to get high enough concentrations in the target organs.
Dose limiting signs (toxicity) were seen at very high repeated doses in animals.
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