AICp - page 4 of the protocol paper - in the section on...

AICp - page 4 of the protocol paper - in the section on statistical considerations.

The adjudication rates between the Aussie and US doctors were roughly equivalent. The reason for the slight difference will be due to study implementation.

In the Australian studies the researchers are the clinicians in the hospital and have the leverage (and care factor) to ensure high quality information is collected during the study period.

In the US there is a strict separation between clinical and research functions. And the researchers have little ability to influence the quality of information that clinicians produce in routine practice.

Poorer quality information will produce lower rates of adjudication agreement.

I appreciate AICp that as layperson this stuff is not simple to understand. But posting prolifically doesn't actually make you know anything better.