You never got answers to your excellent questions.
Pity, I would have liked to see the answers.
I think that it's almost always non-GMP grade in preclinicals because:
* cost
* staying under the radar
* non-human animals aren't fussy
Yes, the readout of the next stage of the melanoma preclinical may bring about some BP attention.
Ann: Preclinical & Clinical Programs Update, page-187
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