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6.0¢ rhythm biosciences limited

Ann: Proposed issue of securities - RHY, page-18

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goedy

461 Posts.

96

09/02/24

16:23

Post #: 72329166
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Originally posted by smellyfingers: ↑

"Not only would way more people happily submit to the test but the savings to the health industry of having to avoid a boatload of unnecessary colonoscopies"

Actually, this is incorrect "unnecessary colonoscopies" is driven by the false positive rate that is a function of specificity of the assay. FIT has higher specificity than ColoSTAT (96% versus 91% hence FP rates of 4% and 9% respectively).

In other words, for every 50K people screened (assuming a CRC prevalence of 0.49%) then FIT will produce ~1,800 FP / unnecessary colonoscopies but ColoSTAT will be ~4,500 unnecessary colonoscopies.

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Uh no! FOB will force anyone with any sort of bleed into a colonoscopy. Capture rate for actual CRC following this is around 5%. So 95 % is a waste of time. The false positive for FOB is bullshit high given bleeding can come from numerous other sources, diverticulitis, hemorrhoids ect. A negative for Colostat means NO COLONOSCOPY. Its a huge saving.

RHY Price at posting: 12.5¢ Sentiment: Sell Disclosure: Not Held
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