Hi psych & all, regarding dose escalation given the dosing schedule between PTX-200 & Cytarabine was changed from the previous cohort in an effort to reduce unwanted drug to drug toxicity issues a few patients experienced. I don't believe the AML trial has yet found the maximum PTX-200 tolerated dose, hence upping the next cohort to 45mg/m2. The Phase 1 trial design allows increments of 10mg/m2 up to maximum 55mg/m2 PTX-200 with enrolment estimate up to 40 patients: -
Experimental: PTX-200 and Cytarabine: PTX-200 administered intravenously over 1 hour Phase I: 4 dose levels: 25 to 55 mg/m2 (with reduction to 15 mg/m2 if needed).
It's been a long time & if memory serves we have 3 pCR's out of 18 patients, however for the AML trial I've never seen any mention of ORR, which also includes PR & SD as we did with the Breast & Ovarian. Totally understand pCR is the holy grail of any trial, in my mind ORR is equally important. As this demonstrates if PR & SD are seen then the treatment in addition to any pCR is making a positive % difference to otherwise heavily pre-treated very ill people with little to no other options available. Maybe this is something needed to be raised with management..... & yep agree comms are not the best vs other ASX bio's either....
Anyway fingers crossed we see additional CR/s in the next cohort!
Cheers,
AMS
- Forums
- ASX - By Stock
- Ann: PTX-200 AML Trial Progresses to Higher Dose
Hi psych & all, regarding dose escalation given the dosing...
-
- There are more pages in this discussion • 11 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add PTX (ASX) to my watchlist
|
|||||
Last
4.4¢ |
Change
0.003(7.32%) |
Mkt cap ! $35.43M |
Open | High | Low | Value | Volume |
4.1¢ | 4.4¢ | 4.0¢ | $20.95K | 507.0K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
8 | 216927 | 4.0¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
4.4¢ | 238807 | 2 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
8 | 216927 | 0.040 |
4 | 374358 | 0.039 |
3 | 750222 | 0.038 |
9 | 742682 | 0.037 |
7 | 598944 | 0.036 |
Price($) | Vol. | No. |
---|---|---|
0.044 | 238807 | 2 |
0.045 | 423919 | 4 |
0.046 | 298002 | 2 |
0.047 | 488389 | 2 |
0.048 | 200000 | 1 |
Last trade - 16.10pm 09/07/2024 (20 minute delay) ? |
Featured News
PTX (ASX) Chart |