Ann: Publications Support Optiscan's New Prod, page-2

re: Ann: Publications Support Optiscan's ... Optiscan is pleased to announce the recent publication of key data from both animal and human studies using its confocal microscope devices in the fields of neurosurgery and neuroscience.
The American Journal “Neurosurgery” this month released a supplemental issue (Neurosurg Focus/Volume 36/February 2014) devoted to applications of fluorescence
imaging methods in improving brain tumor resection surgery. Highlights of the supplement included three separate papers releasing data obtained from the use of Optiscan’s
endomicroscopy technology in both human and animal studies:
1.Laser scanning confocal endomicroscopy in the neurosurgical operating room: a review and discussion of future applications
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Potential application of a handheld confocal endomicroscope imaging
system using a variety of fluorophores in experimental gliomas and normalbrain.

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Invivo visualization of GL261-luc2 mouse glioma cells by use of Alexa Fluor–labeled TRP-2 antibodies.

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In the first paper, the authors reported that “The application of confocal imaging into a handheld endomicroscope with in vivo utility has spurred the e
xploration of this technology in the management of brain tumors intraoperatively. When combined with intravenous and topical fluorophores, real-time information about brain neoplasms at the cellular level can be gathered in the operating room”.
The second paper further reported that “handheld confocal microscopy can distinguish between normal brain and neoplastic tissue intraoperatively, which is important for instrument capability if fully implemented to help ensure completeness of glioma resection”.

In each of the first two papers, the authors reviewed extensive data collected using Optiscan’s devices from both humans and animals and reviewed the five previous clinical
(human) reports of neurosurgical endomicroscopy as well as numerous other animal studies.

The third paper represented a longer range view utilising Optiscan’s research instrument, the FIVE-1, to explore the potential of imaging novel molecular markers that
would enable highly specific identification of tumour cells when combined with microscopic imaging as offered by Optiscan’s technology.

These publications complement the outcomes from ongoing activity over recent years utilising Optiscan’s human and animal imaging devices in both clinical and animal studies.
There is now a solid range of published works that establish the utility of these devices,