Ann: Q4 2022 quarterly activity and cash flow report, page-8

More research intoTBI and CTE

If/when FDAapproval is given for Trofinetide in Rett Syndrome we may well have enough cashat hand to explore the potential of NNZ 2591 and the treatment of chronictraumatic encephalopathy (CTE).

The US armythought our treatments had some potential when they funded our TBI studyseveral years ago. That study, as we now know, was actually poorly structuredand the treatment, by and large, was inconsistent (timing of dosage especially),and likely in its dosing (ie. under dosing).

This is ahuge area of need, and so a great, unmet market. Could be worth another shot,in a well-constructed trial.

UNSW research onthe effects of concussion and TBI (CTE) just released states ...

“Experiencingmultiple concussions may be linked to worse brain function in later life,suggests a study of nearly 16,000 people.

Among 15,764 peopleaged 50 to 90, those who reported three or more concussions had worse complexplanning and attention scores on a range of cognitive tests.

People who hadexperienced four or more concussions showed poorer attention, processing speedand working memory.

“What we found wasthat … you only really need to have three lifetime concussions to have somekind of cognitive deficits in the long term,” said Dr Matthew Lennon, thestudy’s lead author and a PhD candidate at the University of New South Wales’sCentre for Healthy Brain Ageing.”

It goes on ...

“A large and growing body of scientific evidence has shown linksbetween repeated exposure to head injury and sub-concussive blows in contactsports and the neurodegenerative disease chronic traumatic encephalopathy(CTE), which has been found in the brains of multiple Australiansportspeople, from amateurs to professionals.”

I wouldn’t be surprised if the UNSW team was interested in joiningNEU in a new, smaller and well-structured trial. After all, we do have the ‘Aspirin for the Brain’, and we are/will be further 'cashed up'.