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clock Created with Sketch. 31/01/25
17:40
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Originally posted by fourdollars
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Hi Davisite, "Recruitment of the additional three participants into cohort 4of the dose escalation phase of the SECuRE trial is nowcomplete, and the participants are currently in the safety andefficacy follow-up period with final participant completing finaldose as planned." What does this mean? They've each had one dose? Two doses? Why is this being referred to the "final dose as planned"? Aren't they each supposed to have 4 doses?· - the first 3 patientsin Cohort 4 will receive their 3rd dose of 12GBq in November (this still hasn't happended) · - the second 3patients in Cohort 4 will receive their 1st dose of 12GBq inNovember (don't think this happened) · - the first 3 patientsin Cohort 4 will receive their 4th dose of 12GBq in February-25 ( no chance of this happening) · - the second 3patients in cohort 4 will receive their 2nd dose of 12GBq inFebruary-25 ( confusing bit. Can't imagine that the company will progresses this faster than BP's guesstimate, yet the company claims that "the participants are currently in the safety andefficacy follow-up period with final participant completing finaldose as planned") · - the expansion cohortwill commence dosing after the next safety Review Committee meeting inlate-Feb. (maybe. Company saying "this quarter") · - Final data fromcohort 4 is not expected until Q3-2025 · - Final data from theSECURE trial in H2-2025
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I am just commenting on the modest burn rate given the number of trials underway in the USA, along with the scale-up in manufacturing required.
(20min delay)