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https://pubmed.ncbi.nlm.nih.gov/27592597/
Treatment of Type 1 Diabetes
Shinichi Matsumoto 1 , Adrian Abalovich 2 , Carlos Wechsler 2 , Shaun Wynyard 3 , Robert B Elliott 4
Affiliations
Free PMC article
- PMID: 27592597
- PMCID: PMC5078586
- DOI: 10.1016/j.ebiom.2016.08.034
Abstract
Background: Allogeneic islet transplantation has become a viable option for the treatment of unstable type 1 diabetes. However, the donor shortage and the necessity of the immunosuppressive drugs are two major issues. To solve these issues, we performed islet xenotransplantation using encapsulated neonatal porcine islets without immunosuppressive drugs.
Methods: Two different doses (approximately 5000IEQ/kg and 10,000IEQ/kg) of encapsulated neonatal porcine islets were transplanted twice (total approximately 10,000IEQ/kg and 20,000IEQ/kg) into four type 1 diabetic patients in each group (total 8 patients).
Findings: In the higher dose group, all four patients improved HbA1c. This was maintained at a level of <7% for >600days with significant reduction of the frequency of unaware hypoglycemic events.
Interpretation: The clinical benefit of islet xenotransplantation with microencapsulation has been shown.
Keywords: Encapsulation; Islet transplantation; PERV; Porcine islet; Type 1 diabetes; Xenotransplantation.
Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
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