And bleach would show a 9-log reduction given the exact same...

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zecs

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08/07/24

22:02

Post #: 74662369
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Originally posted by rl: ↑

I thought readers might be interested in how significant a "log reduction" number is in terms of efficacy in killing bacteria.
I asked Bing Copilot.... "what is the meaning of a log reduction in health research studies" and the answer came back.

Log Reduction Explained:A log reduction quantifies the reduction in microbial load using a logarithmic scale. Each “log” represents a tenfold reduction in the number of microorganisms.For instance:

A 1-log reduction means the number of germs is 10 times smaller.
A 2-log reduction means the number of germs is 100 times smaller.
A 3-log reduction corresponds to a 1000-fold reduction in microbial load, and so on.

Relationship Between Log Reduction and Percent Reduction:Microbiologists often express log reductions using scientific notation. To make these numbers more manageable, they use logarithmic scales.Here’s a pattern that helps relate log reductions to percent reductions:

1 log reduction = 90% reduction
2 log reduction = 99% reduction
3 log reduction = 99.9% reduction
4 log reduction = 99.99% reduction
5 log reduction = 99.999% reduction
6 log reduction = 99.9999% reduction

In the context of the RCE announcement it seems like these were very good results..

Key Findings from the study include:
• 1-hour Post-treatment Efficacy: Within the first hour post-treatment of invasive
(intracellular) Multidrug-Resistant A. baumannii in primary human epidermal keratinocytes,
R327 achieved a >6.5 log reduction, rendering the bacteria below the limit of quantification
(BLOQ). This demonstrates the rapid and effective bactericidal action of R327. In contrast,
ciprofloxacin did not show any reduction in intracellular bacterial burden at this early
timepoint.
• 24-hour Sustained Efficacy: R327 maintained its efficacy at >6.5 log or >99.9999%
reduction in intracellular bacteria even after 24 hours, a critical factor in infection
management. In comparison, ciprofloxacin treatment only resulted in ~1 log reduction in
bacterial numbers over the same period.
The WHO has listed A. baumannii as one of the top priority pathogens due to its high levels of
resistance to multiple antibiotics. A. baumannii is now a significant global health threat, known for
causing severe infections, both in hospital settings and within the community

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And bleach would show a 9-log reduction given the exact same experiment!

We get it. R327 kills every single pathogen in a test tube. They don't need to keep running this experiment over and over again. Eight years of essentially the same experiment.

They need to show results in a human. Even an infected mouse would be great.

Yet, the only experiments that used sick humans are unable to recruit. The burns trial was abandoned after recruiting 4 patients in a year and a half. The current DFI trial is headed the same way, having recruited only 5 patients in over a year. If the pixie juice worked, word would spread, and they would be fighting off participants.

RCE Price at posting: 45.5¢ Sentiment: None Disclosure: Held
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