Not only pricing, but if Zantrene was approved for AML and made available as a single agent, wouldn't that effectively prevent altogether or at least greatly reduce the appeal of any licensing deals?
It would seem to me that there wouldn't be a lot of value for anyone to license Zantrene and develop a combination to sell as a high value product, extend patent life of their existing drugs, etc. if that could be effectively bypassed by buying the drugs separately and then using them together.
As I understand it, once a drug is approved for a single indication there isn't much that could be done to prevent it being used off label in this manner.
The exception to this could perhaps be the different formulations of Zantrene where the IV formulation may for example be kept for licensing while getting approval for the original formulation.
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