Trastuzumab (Herceptin) cardiotoxicity MOA causes oxidative stress and increased ROS production. If Zantrene dials down these pathways via iron metabolism then it’s common MOA for anthracycline and Proteasome inhibitors. This would be a big win!
Trastuzumab Cardiotoxicity
https://www.mdpi.com/2076-3921/12/2/457
Carfilzomib cardiotoxicity
https://link.springer.com/article/10.1007/s11912-020-00931-w
Doxorubicin Cardiotoxicity
https://www.sciencedirect.com/science/article/pii/S1043661820313700
Cardiotoxicity (Iron, Oxidative Stress, ROS)
https://doi.org/10.1016/j.biopha.2021.111708
https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=cfdadcb217bd77ae5697f80f0b5008536fcdf18e
Ann: Race releases complete cardio-protection data & video, page-65
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