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16:46
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Originally posted by JBeez_:
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A question I had regarding the cancelling of the non-interventional phase of the cardio-protection trial was, how do RAC plan to show an improvement (or a reduction) in cardiotoxicity when for most patients, it takes many years to manifest. Often well after the cancer is in remission or years after any trial follow up has finished. Taken from the strategic update itself "several studies have estimated that over half of the patients exposed to anthracyclines will develop some form of heart disease within six years of treatment."We need clear communication as to how cardiotoxicity is going to be demonstrated in the trials. Strategic Update: Overall thoughts: I think now the strategy has been clearly defined, we are in a stronger position to reach commercialization, but theres likely dilution and a hell of a lot of patience required to get there.
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Heart damage might have no noticeable symptoms for years, but even tiny amounts of early damage can be measured
(20min delay)