The significance of CRP level is that it is an indication of...

The significance of CRP level is that it is an indication of current inflammation.
So Rem-L works if you are currently suffering from disease progression as signified by inflammation markers and doesn't work if you are already at the end point of the disease that left you with COPD. It's the same result as the CHF and I expect it is the same as the Covid-ARDS data - Rem-L works best when you are at the earlier stages, where disease progression is occurring and where the body is reacting with severe inflammation.
If your cohort has long-term COPD sufferers who are now operating with damaged organs it does not rejuvenate them. The key here is to now only conduct trials with clear inflammation markers present in the patients. Rem-L's mode of operation has always been to rapidly reduce inflammation so it makes sense to only use it to treat patients that are showing clear bio-markers of inflammation.