Chin up lads, any Pharma looking to License/Acquire the pipeline...

Chin up lads, any Pharma looking to License/Acquire the pipeline will, unlike the market, see the significant differentials in dosing between;

FXS:  
Higher dose (70 mg/kg twice daily) demonstrated a consistent pattern of clinical improvement ( effects observed following treatment with the low dose of trofinetide (35 mg/kg twice daily) were less consistent and the magnitude of improvement did not meet pre-specified targets, but there was evidence of a dose response)

Rett:  
Higher dose (70mg/kg twice daily) exceeded the pre-specified criteria for improvement in core efficacy measures compared with placebo (The lower dose level (35mg/kg twice daily) exhibited improvement in a number of core outcome measures, however the magnitude of improvement did not meet the targets pre-specified in the analysis plan.)

TBI:
bolus 20 mg/kg followed by 1, 3 or 6 mg/kg per hour for 72 hours