Ann: Results show MPL suppresses biomarkers associated with MND, page-200

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Jockthegreat

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19/07/23

09:37

Post #: 68858127
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Originally posted by Peeteepoo: ↑

For those suggesting cohort 2 results are due. Is there going to be further releases prior to the end of the trial ? I'm not saying there wont be, just that I don't know.

We have had part of the interim report released, which so far appear to be restricted to cohort 1. So the NFL spinal fluid results and hopefully a report bringing all the test results together with cognitive testing will be released soon. Which if comprehensive and positive could be a very big thing. I think we all agree with that, so fingers crossed.

But I'm not sure there will be more testing prior to the trial end. Personally I hope each cohort will be updated, but I don't recall seeing that. Does anyone know for sure ?

It may be like statements made on the forum that stated once each cohort was completed it would be straight into the next, followed by complaints this didn't happen. We then found out this is not the way it works as the results had to go past the safety committee first.

Just curious. If anyone knows otherwise I will be happy to be wrong.

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Peeteepoo, my only thought on this is...how do you best determine the optimum phase 2 dose without these markers for each dose?

I guess you could base it on adverse effects only, so go to highest dose that shows no adverse effects. But this doesnt seem optimal.

Surely to give a potential phase 2 the best shot they'll take these samples across all dosing regimes? But possibly they won't publish them to the mushrooms.

PAA Price at posting: 8.1¢ Sentiment: Hold Disclosure: Held
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