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Peeteepoo, my only thought on this is...how do you best...

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    Peeteepoo, my only thought on this is...how do you best determine the optimum phase 2 dose without these markers for each dose?

    I guess you could base it on adverse effects only, so go to highest dose that shows no adverse effects. But this doesnt seem optimal.

    Surely to give a potential phase 2 the best shot they'll take these samples across all dosing regimes? But possibly they won't publish them to the mushrooms.
 
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