And yet another blow for an Ionis CNS antisense drug candidate….
Following the announcement last October of Phase 3 failure of tofersen in adults with ALS associated with a SOD1 mutation, Biogen and Ionis have suffered another disappointment in the ALS pipeline after BIIB078 (IONIS-C9Rx) failed to demonstrate clinical benefit in a 106 patient Phase 1 trial. BIIB078 is an investigational antisense therapy for the treatment of C9orf72-associated ALS.
No consistent difference was seen between the 60mg cohort and placebo and the 90mg cohort showed a greater decline on secondary endpoints than placebo.
https://www.prnewswire.com/news-rel...-amyotrophic-lateral-sclerosis-301511359.html
https://www.fiercebiotech.com/biote...t-quits-als-med-after-it-flunks-phase-1-trial
https://pharmaphorum.com/news/new-b...ogen-and-ionis-candidate-fails-phase-1-trial/
- Forums
- ASX - By Stock
- PYC
- Ann: Retina Target Engagement Confirmed in Large Eye
Ann: Retina Target Engagement Confirmed in Large Eye, page-84
-
- There are more pages in this discussion • 11 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add PYC (ASX) to my watchlist
|
|||||
Last
11.0¢ |
Change
-0.005(4.35%) |
Mkt cap ! $513.2M |
Open | High | Low | Value | Volume |
11.5¢ | 11.8¢ | 11.0¢ | $297.5K | 2.621M |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
12 | 1372418 | 11.0¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
11.5¢ | 390472 | 6 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
10 | 272418 | 0.110 |
13 | 1962835 | 0.105 |
13 | 954572 | 0.100 |
1 | 5100 | 0.098 |
1 | 10000 | 0.096 |
Price($) | Vol. | No. |
---|---|---|
0.115 | 50000 | 1 |
0.120 | 313000 | 4 |
0.125 | 553388 | 5 |
0.130 | 695661 | 9 |
0.135 | 919367 | 11 |
Last trade - 16.10pm 19/07/2024 (20 minute delay) ? |
Featured News
PYC (ASX) Chart |